SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Abstract SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses.It remains elusive shiro neon zero how human somatic stem cell populations might be impacted by SIRT7.Here, we found that SIRT7 expression declines during human mesenchymal stem cell (hMSC) aging and that SIRT7 deficiency accel